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Substance abuse can often be treated and effectively controlled.

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Your brain is wired to search for similar situations to what makes you feel good. You will be motivated to repeat these acts frequently.
You brain's reward system is the target of drugs that could lead to addiction. Your brain gets large amounts of the chemical dopamine. This causes a state of happiness that can only be described as total happiness. You continue taking the drug to try and get there again.
Your brain will start to adapt to the higher levels of dopamine. You may have to consume more medication to achieve the same effect. Additionally, once enjoyable activities such as eating and spending time together with family might no longer be so pleasurable.

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When a person keeps taking drugs, their brain adjusts by making cells in the reward circuit less able to respond to it. As long as the person keeps using drugs, this will keep happening. This is called tolerance, and it makes the person feel less high than they did when they first took the drug. They could try to get the same high by taking in more of the substance. Because of these changes in the brain, the person often can't find pleasure in things they used to enjoy, like eating, being sexual, or being with other people.
Long-term use also changes other chemical systems and circuits in the brain, which can affect learning, judgement, decision-making, stress, memory, and behaviour. Because of how addiction works, many people who use drugs keep doing it even though they know the bad things that could happen if they keep doing it.

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The hallmark of addiction is an inability to quit. Absolutely not when doing so puts your health at jeopardy. No, not when it creates financial, emotional, and other kinds of difficulties for you or the people you care about. Even if you wish to stop using drugs, you can find that the need to get and use them consumes every waking moment of the day.

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Your brain adapts to the additional dopamine over time. To get the same feeling, you may need to take more dopamine. You may also find that other activities, such as food or spending time with loved ones, give you less pleasure.
Long-term use of drugs can lead to changes in brain circuits and chemical systems. They can affect your judgment, decision-making, memory, ability to learn, and judgement. These brain changes, when combined, can cause you to look for and take drugs in ways beyond your control.

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If someone relapses, they will make an effort not to use drugs again. A relapse indicates that more treatment or a new therapeutic approach are needed.
The majority of medications work by overloading the brain's reward network with high levels of the chemical messenger, dopamine. The reward circuit's dopamine surges are what encourage harmful and enjoyable behaviors. This is why people are more inclined to engage in these harmful behaviors repeatedly.
The brain develops tolerance over time. It adjusts to the dopamine and the effects it has on the body. They may use more of the drug to enjoy the same dopamine high.

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In the majority of cases, drugs work by increasing brain dopamine's reward system. Dopamine released from rewarding behaviour can reinforce it and lead to dangerous, yet gratifying, behavior. Therefore, people are more likely repeat the same actions.
The brain adapts to the dopamine and the tolerance occurs. This means that the person's high is less than it was when they first took the medication. To receive as much dopamine and as many as possible, they may increase their dosage.